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Recent studies have shed new light on the understanding of phosphate metabolism. Human FGF23 was cloned by using sequence homology with mouse FGF23 (Yamashita, T. FGF23 was cloned initially from mice using PCR methods based on sequences derived from database searches using sequence homology with FGF15. BACKGROUND OF THE INVENTIONįibroblast growth factor-23 (FGF23 or FGF-23) is a hormone that regulates phosphate level through an action on the reabsorption of phosphate from the kidneys.

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The contents of the text file submitted electronically herewith are incorporated herein by reference in their entirety: A computer readable format copy of the Sequence Listing (filename: ULPI_022_02US_SeqList_ST25.txt, date created: Mar. DESCRIPTION OF TEXT FILE SUBMITTED ELECTRONICALLY

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The present invention relates to compositions comprising an active ingredient regulating bone formation, and methods of using the compositions. 9, 2014, which is herein incorporated by reference in its entirety for all purposes.

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This application is a Continuation Application of U.S.

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